Target：CyPB

Gene Name：PPIB

Protein Name：Peptidyl-prolyl cis-trans isomerase B

Human Gene Id：5479

Human Swiss Prot No：P23284

Mouse Gene Id：19035

Mouse Swiss Prot No：P24369

Rat Gene Id：64367

Rat Swiss Prot No：P24368

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human PPIB. AA range:151-200

Specificity：CyPB Polyclonal Antibody detects endogenous levels of CyPB protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPIB;CYPB;Peptidyl-prolyl cis-trans isomerase B;PPIase B;CYP-S1;Cyclophilin B;Rotamase B;S-cyclophilin;SCYLP

Observed Band(KD)：24kD

Background： The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],

Function：catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,

Subcellular Location：Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Expression： Brain,Fetal brain cortex,Prostate,Skin,