Target：CYP3A7

Fields：Steroid hormone biosynthesis;Retinol metabolism;Metabolic pathways;Chemical carcinogenesis - DNA adducts

Gene Name：CYP3A7

Protein Name：Cytochrome P450 3A7

Human Gene Id：1551

Human Swiss Prot No：P24462

Immunogen：The antiserum was produced against synthesized peptide derived from human Cytochrome P450 3A7. AA range:231-280

Specificity：CYP3A7 Polyclonal Antibody detects endogenous levels of CYP3A7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CYP3A7;Cytochrome P450 3A7;CYPIIIA7;Cytochrome P450-HFLA

Observed Band(KD)：50kD

Background： This gene encodes a member of the cytochrome P450 superfamily of enzymes, which participate in drug metabolism and the synthesis of cholesterol, steroids and other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015],

Function：catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.,induction:P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.,online information:CYP3A7 alleles,similarity:Belongs to the cytochrome P450 family.,

Subcellular Location：Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane ; Peripheral membrane protein.

Expression：Expressed in fetal liver (at protein level).