Target：CYP2S1

Fields：Retinol metabolism;Metabolism of xenobiotics by cytochrome P450;Metabolic pathways

Gene Name：CYP2S1

Protein Name：Cytochrome P450 2S1

Human Gene Id：29785

Human Swiss Prot No：Q96SQ9

Mouse Gene Id：74134

Mouse Swiss Prot No：Q9DBX6

Immunogen：The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2S1. AA range:181-230

Specificity：CYP2S1 Polyclonal Antibody detects endogenous levels of CYP2S1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CYP2S1;Cytochrome P450 2S1;CYPIIS1

Observed Band(KD)：56kD

Background： This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. [provided by RefSeq, Jul 2008],

Function：catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Has a potential importance for extrahepatic xenobiotic metabolism.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:High level of expression in trachea, lung, stomach, small intestine, and spleen.,

Subcellular Location：Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

Expression：Expressed at higher levels in extrahepatic tissues including trachea, lung, stomach, small intestine, colon, kidney, breast, placenta and spleen (PubMed:11181079, PubMed:12711469). Expressed in peripheral blood leukocytes (PubMed:11181079). Constitutively expressed in skin (at protein level) (PubMed:12711469).