Target：RIT2

Gene Name：RIT2 RIN ROC2

Protein Name：GTP-binding protein Rit2 (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)

Human Gene Id：6014

Human Swiss Prot No：Q99578

Mouse Swiss Prot No：P70425

Rat Swiss Prot No：Q5BJQ5

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：RIT2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：23kD

Background： RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008],

Function：function:Binds and exchanges GTP and GDP.,miscellaneous:Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin.,tissue specificity:Neuron-specific.,

Subcellular Location：Nucleus . Cell membrane . Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). .

Expression：Neuron-specific.