Target：GBP1

Fields：NOD-like receptor signaling pathway

Gene Name：GBP1

Protein Name：Interferon-induced guanylate-binding protein 1

Human Gene Id：2633

Human Swiss Prot No：P32455

Mouse Swiss Prot No：Q01514

Immunogen：The antiserum was produced against synthesized peptide derived from human GBP1. AA range:71-120

Specificity：GBP1 Polyclonal Antibody detects endogenous levels of GBP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GBP1;Interferon-induced guanylate-binding protein 1;GTP-binding protein 1;GBP-1;HuGBP-1;Guanine nucleotide-binding protein 1

Observed Band(KD)：68kD

Background： Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008],

Function：function:Binds GTP, GDP and GMP.,induction:By interferon gamma during macrophage activation.,similarity:Belongs to the GBP family.,

Subcellular Location：Cytoplasm . Golgi apparatus membrane; Lipid-anchor ; Cytoplasmic side. Cell membrane . Secreted . Cytoplasmic vesicle . Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.

Expression： Placenta,Spleen,Uterus,