Target：GBLP

Fields：Measles

Gene Name：GNB2L1 HLC7 PIG21

Protein Name：Guanine nucleotide-binding protein subunit beta-2-like 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7

Human Gene Id：10399

Human Swiss Prot No：P63244

Mouse Swiss Prot No：P68040

Rat Swiss Prot No：P63245

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：GBLP Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：34kD

Background：domain:The WD repeats domain 5 mediates interaction with TRIM63.,function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells.,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,

Function：domain:The WD repeats domain 5 mediates interaction with TRIM63.,function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation.,similarity:Belongs to the WD repeat G protein beta family.,similarity:Contains 7 WD repeats.,subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells.,subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.,

Subcellular Location：Cell membrane ; Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). .

Expression：In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.