Target：Cyclophilin F
Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Neutrophil extracellular trap formation;Alzheimer disease;Parkinson disease;Huntington disease;Spinocerebellar ataxia;Prion disease;Pathways of neurodegeneration - multiple diseases;Toxoplasmosis;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy
Gene Name：PPIF
Protein Name：Peptidyl-prolyl cis-trans isomerase F mitochondrial
Human Gene Id：10105
Human Swiss Prot No：P30405
Mouse Gene Id：105675
Mouse Swiss Prot No：Q99KR7
Rat Gene Id：282819
Rat Swiss Prot No：P29117
Immunogen：The antiserum was produced against synthesized peptide derived from human PPIF. AA range:86-135
Specificity：Cyclophilin F Polyclonal Antibody detects endogenous levels of Cyclophilin F protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PPIF;CYP3;Peptidyl-prolyl cis-trans isomerase F; mitochondrial;PPIase F;Cyclophilin F;Rotamase F
Observed Band(KD)：22kD
Background： The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008],
Function：catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,function:PPIases accelerate the folding of proteins.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Contains 1 PPIase cyclophilin-type domain.,
Subcellular Location：Mitochondrion matrix .
Expression： Blood,Cord blood,Ovary,
