Target：CY24A

Fields：Phagosome;Osteoclast differentiation;Neutrophil extracellular trap formation;NOD-like receptor signaling pathway;Leukocyte transendothelial migration;Prion disease;Leishmaniasis;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis

Gene Name：CYBA

Protein Name：Cytochrome b-245 light chain (Cytochrome b(558) alpha chain) (Cytochrome b558 subunit alpha) (Neutrophil cytochrome b 22 kDa polypeptide) (Superoxide-generating NADPH oxidase light chain subunit) (p22

Human Gene Id：1535

Human Swiss Prot No：P13498

Mouse Swiss Prot No：Q61462

Rat Swiss Prot No：Q62737

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：CY24A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：21kD

Background： Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008],

Function：disease:Defects in CYBA are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-negative (ARCGD) [MIM:233690]. Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.,function:Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.,miscellaneous:The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.,online information:CYBA mutation db,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the p

Subcellular Location：Cell membrane . As unassembled monomer may localize to the endoplasmic reticulum. .

Expression： Brain,