Target：CTND2

Fields：Wnt signaling pathway

Gene Name：CTNND2 NPRAP

Protein Name：Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin)

Human Gene Id：1501

Human Swiss Prot No：Q9UQB3

Mouse Swiss Prot No：O35927

Rat Swiss Prot No：O35116

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CTND2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：134kD

Background：catenin delta 2(CTNND2) Homo sapiens This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],

Function：alternative products:Additional isoforms seem to exist,function:Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules.,PTM:O-glycosylated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the beta-catenin family.,similarity:Contains 9 ARM repeats.,subunit:Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with RGNEF.,tissue specificity:Predominantly expressed in brain.,

Subcellular Location：Nucleus . Cell junction, adherens junction . Cell projection, dendrite . Perikaryon .

Expression：Expressed in brain; highest expression is observed in fetal brain (PubMed:25807484).