Target：CSPP1

Gene Name：CSPP1 CSPP

Protein Name：Centrosome and spindle pole-associated protein 1

Human Gene Id：79848

Human Swiss Prot No：Q1MSJ5

Mouse Swiss Prot No：B2RX88

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：CSPP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：138kD

Background：centrosome and spindle pole associated protein 1(CSPP1) Homo sapiens This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

Function：developmental stage:Expression of isoform 1 increases throughout the cell cycle and peaks in G2/M phase. Expression of isoform 2 is highest in G1 phase and decreases thereafter.,function:May play a role in cell-cycle-dependent microtubule organization.,PTM:Phosphorylated. Phosphorylation increases in colcemide-treated cells.,subcellular location:Associated with mitotic spindles.,tissue specificity:Detected in testis.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole . Associated with mitotic spindles.

Expression：Expressed in adult and fetal brain with enrichment in the cerebellum. Detected in testis.