Target：CSP

Fields：Protein processing in endoplasmic reticulum

Gene Name：DNAJC5

Protein Name：DnaJ homolog subfamily C member 5

Human Gene Id：80331

Human Swiss Prot No：Q9H3Z4

Mouse Gene Id：13002

Mouse Swiss Prot No：P60904

Rat Gene Id：79130

Rat Swiss Prot No：P60905

Immunogen：The antiserum was produced against synthesized peptide derived from human DNAJC5. AA range:131-180

Specificity：CSP Polyclonal Antibody detects endogenous levels of CSP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DNAJC5;CSP;DnaJ homolog subfamily C member 5;Cysteine string protein;CSP

Observed Band(KD)：30kD

Background： This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010],

Function：function:May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings.,PTM:Fatty acylated. Heavily palmitoylated in the cysteine string motif.,similarity:Contains 1 J domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,tissue specificity:Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.,

Subcellular Location：Cytoplasm, cytosol . Membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane . Melanosome . Cell membrane . The association with membranes is regulated by palmitoylation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Expression：Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.