Target：CRSP70

Gene Name：MED26

Protein Name：Mediator of RNA polymerase II transcription subunit 26

Human Gene Id：9441

Human Swiss Prot No：O95402

Mouse Gene Id：70625

Mouse Swiss Prot No：Q7TN02

Immunogen：The antiserum was produced against synthesized peptide derived from human MED26. AA range:1-50

Specificity：CRSP70 Polyclonal Antibody detects endogenous levels of CRSP70 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MED26;ARC70;CRSP7;Mediator of RNA polymerase II transcription subunit 26;Activator-recruited cofactor 70 kDa component;ARC70;Cofactor required for Sp1 transcriptional activation subunit 7;CRSP complex subunit 7;Mediator complex subu

Observed Band(KD)：65kD

Background： The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008],

Function：function:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.,similarity:Belongs to the Mediator complex subunit 26 family.,similarity:Contains 1 TFIIS N-terminal domain.,subunit:Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and C

Subcellular Location：Nucleus .

Expression： Epithelium,Uterus,