Target：CRF-RII

Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Cushing syndrome

Gene Name：CRHR2

Protein Name：Corticotropin-releasing factor receptor 2

Human Gene Id：1395

Human Swiss Prot No：Q13324

Mouse Swiss Prot No：Q60748

Rat Gene Id：64680

Rat Swiss Prot No：P47866

Immunogen：The antiserum was produced against synthesized peptide derived from human CRHR2. AA range:71-120

Specificity：CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CRHR2;CRF2R;CRH2R;Corticotropin-releasing factor receptor 2;CRF-R-2;CRF-R2;CRFR-2;Corticotropin-releasing hormone receptor 2;CRH-R-2;CRH-R2

Observed Band(KD)：48kD

Background： The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],

Function：function:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,similarity:Belongs to the G-protein coupled receptor 2 family.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression： Amygdala,Brain,Skeletal muscle,