Target：CPTI-M

Fields：Fatty acid degradation;Fatty acid metabolism;PPAR signaling pathway;AMPK signaling pathway;Thermogenesis;Adipocytokine signaling pathway;Glucagon signaling pathway;Insulin resistance;Alcoholic liver disease;Diabetic cardiomyopathy

Gene Name：CPT1B

Protein Name：Carnitine O-palmitoyltransferase 1 muscle isoform

Human Gene Id：1120/1375

Human Swiss Prot No：Q92523

Mouse Swiss Prot No：Q924X2

Immunogen：The antiserum was produced against synthesized peptide derived from human CPT1B. AA range:401-450

Specificity：CPTI-M Polyclonal Antibody detects endogenous levels of CPTI-M protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CPT1B;KIAA1670;Carnitine O-palmitoyltransferase 1; muscle isoform;CPT1-M;Carnitine O-palmitoyltransferase I, muscle isoform;CPT I;CPTI-M;Carnitine palmitoyltransferase 1B;Carnitine palmitoyltransferase I-like protein

Observed Band(KD)：88kD

Background： The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. [provided by RefSeq, Jun 2009],

Function：catalytic activity:ATP + choline = ADP + O-phosphocholine.,catalytic activity:ATP + ethanolamine = ADP + O-phosphoethanolamine.,catalytic activity:Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.,miscellaneous:This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.,miscellaneous:This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,similarity:Belongs to the choline/ethanolamine kinase family.,tissue specificity:Strong expression in heart and skeletal muscle. No expression in liver and kidney.,

Subcellular Location：Mitochondrion outer membrane ; Multi-pass membrane protein .

Expression：Strong expression in heart and skeletal muscle. No expression in liver and kidney.