Target：GATA-2/3
Fields：Th1 and Th2 cell differentiation;Th17 cell differentiation;Parathyroid hormone synthesis, secretion and action;Inflammatory bowel disease
Gene Name：GATA2/GATA3
Protein Name：rans-acting T-cell-specific transcription factor GATA-2/3
Human Gene Id：2625
Human Swiss Prot No：P23771/P23769
Mouse Gene Id：14462/14461
Immunogen：The antiserum was produced against synthesized peptide derived from human GATA3. AA range:274-323
Specificity：GATA-2/3 Polyclonal Antibody detects endogenous levels of GATA-2/3 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GATA3;Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3;GATA2;Endothelial transcription factor GATA-2;GATA-binding protein 2
Molecular Weight(Da)：48kD
Background： This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
Function：disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
Subcellular Location：Nucleus.
Expression：T-cells and endothelial cells.
