Target：COX5b

Fields：Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Thermogenesis;Non-alcoholic fatty liver disease;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Huntington disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：COX5B

Protein Name：Cytochrome c oxidase subunit 5B mitochondrial

Human Gene Id：1329

Human Swiss Prot No：P10606

Mouse Swiss Prot No：P19536

Rat Gene Id：94194

Rat Swiss Prot No：P12075

Immunogen：The antiserum was produced against synthesized peptide derived from human COX5B. AA range:11-60

Specificity：COX5b Polyclonal Antibody detects endogenous levels of COX5b protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：COX5B;Cytochrome c oxidase subunit 5B; mitochondrial;Cytochrome c oxidase polypeptide Vb

Molecular Weight(Da)：14kD

Background： Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. [provided by RefSeq, Jul 2008],

Function：function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase subunit 5B family.,

Subcellular Location：Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

Expression： Liver,Skin,