Target：COX4I2

Fields：Oxidative phosphorylation;Metabolic pathways;Cardiac muscle contraction;Thermogenesis;Non-alcoholic fatty liver disease;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Huntington disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：COX4I2

Protein Name：Cytochrome c oxidase subunit 4 isoform 2 mitochondrial

Human Gene Id：84701

Human Swiss Prot No：Q96KJ9

Mouse Gene Id：84682

Mouse Swiss Prot No：Q91W29

Rat Gene Id：84683

Rat Swiss Prot No：Q91Y94

Immunogen：The antiserum was produced against synthesized peptide derived from human COX42. AA range:31-80

Specificity：COX4I2 Polyclonal Antibody detects endogenous levels of COX4I2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：COX4I2;COX4L2;Cytochrome c oxidase subunit 4 isoform 2; mitochondrial;Cytochrome c oxidase subunit IV isoform 2;COX IV-2

Observed Band(KD)：20kD

Background： Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008],

Function：function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Highly expressed in lung.,

Subcellular Location：Mitochondrion inner membrane ; Single-pass membrane protein .

Expression：Highly expressed in lung.