Target：COX17
Fields：Oxidative phosphorylation;Metabolic pathways;Thermogenesis
Gene Name：COX17
Protein Name：Cytochrome c oxidase copper chaperone
Human Gene Id：10063
Human Swiss Prot No：Q14061
Mouse Gene Id：12856
Mouse Swiss Prot No：P56394
Immunogen：The antiserum was produced against synthesized peptide derived from human COX17. AA range:1-50
Specificity：COX17 Polyclonal Antibody detects endogenous levels of COX17 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：COX17;Cytochrome c oxidase copper chaperone
Observed Band(KD)：7kD
Background： Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provi
Function：function:Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.,similarity:Belongs to the COX17 family.,tissue specificity:Ubiquitous.,
Subcellular Location：Mitochondrion intermembrane space . Cytoplasm .
Expression：Ubiquitous.
