Target：COX11

Fields：Oxidative phosphorylation;Metabolic pathways;Thermogenesis

Gene Name：COX11

Protein Name：Cytochrome c oxidase assembly protein COX11 mitochondrial

Human Gene Id：1353

Human Swiss Prot No：Q9Y6N1

Mouse Gene Id：69802

Mouse Swiss Prot No：Q6P8I6

Immunogen：The antiserum was produced against synthesized peptide derived from human COX11. AA range:51-100

Specificity：COX11 Polyclonal Antibody detects endogenous levels of COX11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：COX11;Cytochrome c oxidase assembly protein COX11; mitochondrial

Observed Band(KD)：31kD

Background： Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to c

Function：function:Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.,similarity:Belongs to the COX11/ctaG family.,subunit:Interacts with CNNM4/ACDP4.,tissue specificity:Ubiquitous.,

Subcellular Location：Mitochondrion inner membrane ; Single-pass membrane protein ; Intermembrane side .

Expression：Ubiquitous.