Target：Connexin 46

Gene Name：GJA3

Protein Name：Gap junction alpha-3 protein

Human Gene Id：2700

Human Swiss Prot No：Q9Y6H8

Mouse Gene Id：14611

Mouse Swiss Prot No：Q64448

Rat Gene Id：79217

Rat Swiss Prot No：P29414

Immunogen：The antiserum was produced against synthesized peptide derived from human GJA3. AA range:151-200

Specificity：Connexin 46 Polyclonal Antibody detects endogenous levels of Connexin 46 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GJA3;Gap junction alpha-3 protein;Connexin-46;Cx46

Molecular Weight(Da)：47kD

Background： The protein encoded by this gene is a connexin and is a component of lens fiber gap junctions. Defects in this gene are a cause of zonular pulverulent cataract type 3 (CZP3). [provided by RefSeq, Jan 2010],

Function：disease:Defects in GJA3 are the cause of zonular pulverulent cataract type 3 (CZP3) [MIM:601885]. CZP3 is a form of autosomal dominant congenital cataract.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .

Expression： Lens fibers,