Target：KV3.1

Gene Name：KCNC1

Protein Name：Potassium voltage-gated channel subfamily C member 1

Human Gene Id：3746

Human Swiss Prot No：P48547

Mouse Gene Id：16502

Mouse Swiss Prot No：P15388

Rat Gene Id：25327

Rat Swiss Prot No：P25122

Immunogen：Synthesized peptide derived from KV3.1 . at AA range: 190-270

Specificity：KV3.1 Polyclonal Antibody detects endogenous levels of KV3.1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KCNC1;Potassium voltage-gated channel subfamily C member 1;NGK2;Voltage-gated potassium channel subunit Kv3.1;Voltage-gated potassium channel subunit Kv4

Observed Band(KD)：60kD

Background： This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both "b" and "alpha", while the shorter isoform has been called both "a" and "beta" (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014],

Function：domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,domain:The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.,function:Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the potassium channel family. C (Shaw) subfamily.,subunit:Heteromultimer with KCNG3, KCNG4 and KCNV2.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Localizes in parallel fiber membranes, distributed on the perisynaptic and extrasynaptic membranes away from the active zones. .

Expression： PCR rescued clones,