Target：GAP1-InsP4 BP

Fields：Ras signaling pathway

Gene Name：RASA3

Protein Name：Ras GTPase-activating protein 3

Human Gene Id：22821

Human Swiss Prot No：Q14644

Mouse Gene Id：19414

Mouse Swiss Prot No：Q60790

Rat Gene Id：29372

Rat Swiss Prot No：Q9QYJ2

Immunogen：The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296

Specificity：GAP1-InsP4 BP Polyclonal Antibody detects endogenous levels of GAP1-InsP4 BP protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RASA3;Ras GTPase-activating protein 3;GAP1(IP4BP);Ins P4-binding protein

Observed Band(KD)：95kD

Background： This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

Function：function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,

Subcellular Location：Cell membrane.

Expression： Blood,Brain,Peripheral blood,Platelet,Testis,