Target：GALK1

Fields：Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Metabolic pathways;Biosynthesis of nucleotide sugars

Gene Name：GALK1

Protein Name：Galactokinase

Human Gene Id：2584

Human Swiss Prot No：P51570

Mouse Swiss Prot No：Q9R0N0

Immunogen：The antiserum was produced against synthesized peptide derived from human GALK1. AA range:1-50

Specificity：GALK1 Polyclonal Antibody detects endogenous levels of GALK1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GALK1;GALK;Galactokinase;Galactose kinase

Observed Band(KD)：45kD

Background： Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts during infancy and presenile cataracts in the adult population. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate.,disease:Defects in GALK1 are the cause of galactosemia II [MIM:230200]. It is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.,function:Major enzyme for galactose metabolism.,pathway:Carbohydrate metabolism; galactose metabolism.,similarity:Belongs to the GHMP kinase family.,similarity:Belongs to the GHMP kinase family. GalK subfamily.,

Subcellular Location：cytoplasm,cytosol,membrane,extracellular exosome,

Expression： Blood,Brain,Fetal brain cortex,Lung,