Target：KGP1

Fields：cGMP-PKG signaling pathway;Vascular smooth muscle contraction;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Long-term depression;Olfactory transduction;Regulation of lipolysis in adipocytes;Salivary secretion

Gene Name：PRKG1 PRKG1B PRKGR1A PRKGR1B

Protein Name：cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)

Human Gene Id：5592

Human Swiss Prot No：Q13976

Mouse Swiss Prot No：P0C605

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：KGP1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：73kD

Background： Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-bindin

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,

Subcellular Location：Cytoplasm . Colocalized with TRPC7 in the plasma membrane. .

Expression：Primarily expressed in lung and placenta.