Target：KEPI

Gene Name：PPP1R14C

Protein Name：Protein phosphatase 1 regulatory subunit 14C

Human Gene Id：81706

Human Swiss Prot No：Q8TAE6

Mouse Gene Id：76142

Mouse Swiss Prot No：Q8R4S0

Rat Gene Id：171010

Rat Swiss Prot No：Q8R4R9

Immunogen：The antiserum was produced against synthesized peptide derived from human PPP1R14C. AA range:51-100

Specificity：KEPI Polyclonal Antibody detects endogenous levels of KEPI protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PPP1R14C;KEPI;Protein phosphatase 1 regulatory subunit 14C;Kinase-enhanced PP1 inhibitor;PKC-potentiated PP1 inhibitory protein;Serologically defined breast cancer antigen NY-BR-81

Observed Band(KD)：20kD

Background： The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010],

Function：function:Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in breast cancer.,

Subcellular Location：Cytoplasm . Membrane ; Peripheral membrane protein .

Expression：Detected in breast cancer.