Target：KCNH3

Gene Name：KCNH3

Protein Name：Potassium voltage-gated channel subfamily H member 3

Human Gene Id：23416

Human Swiss Prot No：Q9ULD8

Mouse Swiss Prot No：Q9WVJ0

Rat Gene Id：27150

Rat Swiss Prot No：O89047

Immunogen：Synthesized peptide derived from KCNH3 . at AA range: 470-550

Specificity：KCNH3 Polyclonal Antibody detects endogenous levels of KCNH3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KCNH3;KIAA1282;Potassium voltage-gated channel subfamily H member 3;Brain-specific eag-like channel 1;BEC1;Ether-a-go-go-like potassium channel 2;ELK channel 2;ELK2;Voltage-gated potassium channel subunit Kv12.2

Observed Band(KD)：120kD

Background： The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],

Function：domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly.,similarity:Belongs to the potassium channel family. H (Eag) subfamily.,similarity:Contains 1 cyclic nucleotide-binding domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 PAS (PER-ARNT-SIM) domain.,subunit:The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.,tissue specificity:Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression：Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus.