Target：KCNG2

Gene Name：KCNG2

Protein Name：Potassium voltage-gated channel subfamily G member 2

Human Gene Id：26251

Human Swiss Prot No：Q9UJ96

Rat Gene Id：307234

Rat Swiss Prot No：Q9QYU3

Immunogen：The antiserum was produced against synthesized peptide derived from human KCNG2. AA range:321-370

Specificity：KCNG2 Polyclonal Antibody detects endogenous levels of KCNG2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KCNG2;KCNF2;Potassium voltage-gated channel subfamily G member 2;Cardiac potassium channel subunit;Voltage-gated potassium channel subunit Kv6.2

Observed Band(KD)：51kD

Background： Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008],

Function：domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.,miscellaneous:Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.,similarity:Belongs to the potassium channel family. G subfamily.,subunit:Heterodimer with KCNB1. Does not form homomultimers.,tissue specificity:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.,

Subcellular Location：Membrane; Multi-pass membrane protein.

Expression：Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.