Target：KChIP1

Gene Name：KCNIP1

Protein Name：Kv channel-interacting protein 1

Human Gene Id：30820

Human Swiss Prot No：Q9NZI2

Mouse Gene Id：70357

Mouse Swiss Prot No：Q9JJ57

Rat Gene Id：65023

Rat Swiss Prot No：Q8R426

Immunogen：The antiserum was produced against synthesized peptide derived from human KCIP1. AA range:1-50

Specificity：KChIP1 Polyclonal Antibody detects endogenous levels of KChIP1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KCNIP1;KCHIP1;VABP;Kv channel-interacting protein 1;KChIP1;A-type potassium channel modulatory protein 1;Potassium channel-interacting protein 1;Vesicle APC-binding protein

Molecular Weight(Da)：27kD

Background： This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],

Function：function:Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.,similarity:Belongs to the recoverin family.,similarity:Contains 4 EF-hand domains.,subunit:Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Can self-associate to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3.,tissue specificity:Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform

Subcellular Location：Cell membrane ; Peripheral membrane protein . Cytoplasm . Cell projection, dendrite .

Expression：Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.