Target：K-cadherin

Gene Name：CDH6

Protein Name：Cadherin-6

Human Gene Id：1004

Human Swiss Prot No：P55285

Mouse Gene Id：12563

Mouse Swiss Prot No：P97326

Rat Gene Id：25409

Rat Swiss Prot No：P55280

Immunogen：Synthesized peptide derived from K-cadherin . at AA range: 180-260

Specificity：K-cadherin Polyclonal Antibody detects endogenous levels of K-cadherin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDH6;Cadherin-6;Kidney cadherin;K-cadherin

Observed Band(KD)：88kD

Background： This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011],

Function：function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,tissue specificity:Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.,

Subcellular Location：Cell membrane; Single-pass type I membrane protein.

Expression：Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas.