Target：KALIG-1

Gene Name：KAL1

Protein Name：Anosmin-1

Human Gene Id：3730

Human Swiss Prot No：P23352

Immunogen：The antiserum was produced against synthesized peptide derived from human KAL1. AA range:151-200

Specificity：KALIG-1 Polyclonal Antibody detects endogenous levels of KALIG-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KAL1;ADMLX;KAL;KALIG1;Anosmin-1;Adhesion molecule-like X-linked;Kallmann syndrome protein

Observed Band(KD)：76kD

Background： Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008],

Function：disease:Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1) [MIM:308700]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.,function:May be an adhesion-like molecule with anti-protease activity.,PTM:N-glycosylated.,similarity:Contains 1 WAP domain.,similarity:Contains 4 fibronectin type-III domains.,

Subcellular Location：Cell membrane ; Peripheral membrane protein . Secreted . Proteolytic cleavage may release it from the cell surface into the extracellular space.

Expression：Expressed in the cerebellum (at protein level).