Target：JIK

Fields：MAPK signaling pathway

Gene Name：TAOK3

Protein Name：Serine/threonine-protein kinase TAO3

Human Gene Id：51347

Human Swiss Prot No：Q9H2K8

Mouse Gene Id：330177

Mouse Swiss Prot No：Q8BYC6

Rat Gene Id：304530

Rat Swiss Prot No：Q53UA7

Immunogen：The antiserum was produced against synthesized peptide derived from human TAOK3. AA range:531-580

Specificity：JIK Polyclonal Antibody detects endogenous levels of JIK protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAOK3;DPK;JIK;KDS;MAP3K18;Serine/threonine-protein kinase TAO3;Cutaneous T-cell lymphoma-associated antigen HD-CL-09;CTCL-associated antigen HD-CL-09;Dendritic cell-derived protein kinase;JNK/SAPK-inhibitory kinase;Jun kinase-inhi

Observed Band(KD)：110kD

Background：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.,

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Also localized to the peripheral cell membrane.,subunit:Self-associates.,tissue specificity:Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.,

Subcellular Location：Cytoplasm . Cell membrane ; Peripheral membrane protein . Also localized to the peripheral cell membrane.

Expression：Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.