Target：GABAA Rε

Fields：Neuroactive ligand-receptor interaction;Retrograde endocannabinoid signaling;GABAergic synapse;Morphine addiction;Nicotine addiction

Gene Name：GABRE

Protein Name：Gamma-aminobutyric acid receptor subunit epsilon

Human Gene Id：2564

Human Swiss Prot No：P78334

Immunogen：Synthesized peptide derived from the Internal region of human GABAA range: Rε.

Specificity：GABAA Rε Polyclonal Antibody detects endogenous levels of GABAA Rε protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GABRE;Gamma-aminobutyric acid receptor subunit epsilon;GABA(A) receptor subunit epsilon

Observed Band(KD)：57kD

Background： The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008],

Function：function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. Associates with alpha and beta subunits.,tissue specificity:Expressed in many tissues. Highest levels of expression in adult heart and placenta.,

Subcellular Location：Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Expression：Expressed in many tissues. Highest levels of expression in adult heart and placenta.