Target：IRTKS

Fields：Pathogenic Escherichia coli infection

Gene Name：BAIAP2L1

Protein Name：Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Human Gene Id：55971

Human Swiss Prot No：Q9UHR4

Mouse Gene Id：66898

Mouse Swiss Prot No：Q9DBJ3

Rat Gene Id：304282

Rat Swiss Prot No：Q3KR97

Immunogen：The antiserum was produced against synthesized peptide derived from human BAIAP2L1. AA range:111-160

Specificity：IRTKS Polyclonal Antibody detects endogenous levels of IRTKS protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：BAIAP2L1;IRTKS;Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1;BAI1-associated protein 2-like protein 1;Insulin receptor tyrosine kinase substrate

Observed Band(KD)：57kD

Background： This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal fo

Function：domain:The IMD domain is predicted to have a helical structure. It may induce actin bundling and filopodia formation.,function:May function as adapter protein (Potential). Involved in the formation of clusters of actin bundles.,PTM:Phosphorylated on tyrosine in response to insulin.,similarity:Contains 1 IMD (IRSp53/MIM homology) domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with RAC1. Binds to F-actin.,

Subcellular Location：Cytoplasm, cytoskeleton . Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Expression： Adrenal gland,Epithelium,Lung,Placenta,