Target：IREβ
Gene Name：ERN2
Protein Name：Serine/threonine-protein kinase/endoribonuclease IRE2
Human Gene Id：10595
Human Swiss Prot No：Q76MJ5
Mouse Gene Id：26918
Mouse Swiss Prot No：Q9Z2E3
Immunogen：The antiserum was produced against synthesized peptide derived from human ERN2. AA range:841-890
Specificity：IRE1α/β Polyclonal Antibody detects endogenous levels of IRE1α/β protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ERN2;IRE2;Serine/threonine-protein kinase/endoribonuclease IRE2;Endoplasmic reticulum-to-nucleus signaling 2;Inositol-requiring protein 2;hIRE2p;Ire1-beta;IRE1b
Molecular Weight(Da)：102kD
Background：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
Subcellular Location：Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
Expression： Fetal brain,Fetal lung fibroblast,
