Target：IP Receptor

Fields：Neuroactive ligand-receptor interaction;Vascular smooth muscle contraction;Platelet activation

Gene Name：PTGIR

Protein Name：Prostacyclin receptor

Human Gene Id：5739

Human Swiss Prot No：P43119

Mouse Swiss Prot No：P43252

Immunogen：The antiserum was produced against synthesized peptide derived from human Prostacyclin Receptor. AA range:198-247

Specificity：IP Receptor Polyclonal Antibody detects endogenous levels of IP Receptor protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTGIR;PRIPR;Prostacyclin receptor;Prostaglandin I2 receptor;PGI receptor;PGI2 receptor;Prostanoid IP receptor

Observed Band(KD)：45kD

Background： The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008],

Function：function:Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.,PTM:Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.,PTM:Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.,similarity:Belongs to the G-protein coupled receptor 1 family.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression： Lung,Pancreas,Placenta,