Target：INTS2

Gene Name：INTS2

Protein Name：Integrator complex subunit 2

Human Gene Id：57508

Human Swiss Prot No：Q9H0H0

Mouse Gene Id：70422

Mouse Swiss Prot No：Q80UK8

Immunogen：The antiserum was produced against synthesized peptide derived from human INTS2. AA range:201-250

Specificity：INTS2 Polyclonal Antibody detects endogenous levels of INTS2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：INTS2;KIAA1287;Integrator complex subunit 2;Int2

Observed Band(KD)：140kD

Background： INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008],

Function：caution:It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.,function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the Integrator subunit 2 family.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,

Subcellular Location：Nucleus membrane ; Single-pass membrane protein . Cytoplasm .

Expression： Brain,Testis,