Target：Integrin αL

Fields：Rap1 signaling pathway;Cell adhesion molecules;Neutrophil extracellular trap formation;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Malaria;Staphylococcus aureus infection;Human T-cell leukemia virus 1 infection;Epstein-Barr virus infection;Rheumatoid arthritis;Viral myocarditis

Gene Name：ITGAL

Protein Name：Integrin alpha-L

Human Gene Id：3683

Human Swiss Prot No：P20701

Mouse Swiss Prot No：P24063

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ITGAL. AA range:171-220

Specificity：Integrin αL Polyclonal Antibody detects endogenous levels of Integrin αL protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ITGAL;CD11A;Integrin alpha-L;CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain;CD11a

Observed Band(KD)：130kD

Background：integrin subunit alpha L(ITGAL) Homo sapiens ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-L associates with beta-2.,tissue specificity:Leukocytes.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Leukocytes.