Target：Integrin α5

Fields：Phagosome;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Bacterial invasion of epithelial cells;Shigellosis;Pertussis;Yersinia infection;Human papillomavirus infection;Herpes simplex virus 1 infection;Proteoglycans in cancer;MicroRNAs in cancer;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：ITGA5

Protein Name：Integrin alpha-5

Human Gene Id：3678

Human Swiss Prot No：P08648

Mouse Gene Id：16402

Mouse Swiss Prot No：P11688

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ITGA5. AA range:561-610

Specificity：Integrin α5 Polyclonal Antibody detects endogenous levels of Integrin α5 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ITGA5;FNRA;Integrin alpha-5;CD49 antigen-like family member E;Fibronectin receptor subunit alpha;Integrin alpha-F;VLA-5;CD49e

Observed Band(KD)：115kD

Background：integrin subunit alpha 5(ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

Function：function:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,

Subcellular Location：Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .

Expression： Liver,Placenta,