Target：Integrin α2

Fields：Phagosome;PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Platelet activation;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Human papillomavirus infection;Pathways in cancer;Proteoglycans in cancer;Small cell lung cancer;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：ITGA2

Protein Name：Integrin alpha-2

Human Gene Id：3673

Human Swiss Prot No：P17301

Mouse Gene Id：16398

Mouse Swiss Prot No：Q62469

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human ITGA2. AA range:1081-1130

Specificity：Integrin α2 Polyclonal Antibody detects endogenous levels of Integrin α2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ITGA2;CD49B;Integrin alpha-2;CD49 antigen-like family member B;Collagen receptor;Platelet membrane glycoprotein Ia;GPIa;VLA-2 subunit alpha;CD49b

Observed Band(KD)：130kD

Background：integrin subunit alpha 2(ITGA2) Homo sapiens This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Function：domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.,polymorphism:Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domai

Subcellular Location：Membrane; Single-pass type I membrane protein.

Expression： Endothelial cell,Liver,Platelet,