Target：Inhibin β-A

Fields：Cytokine-cytokine receptor interaction;TGF-beta signaling pathway;Signaling pathways regulating pluripotency of stem cells

Gene Name：INHBA

Protein Name：Inhibin beta A chain

Human Gene Id：3624

Human Swiss Prot No：P08476

Mouse Gene Id：16323

Mouse Swiss Prot No：Q04998

Rat Gene Id：29200

Rat Swiss Prot No：P18331

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human INHBA. AA range:377-426

Specificity：Inhibin β-A Polyclonal Antibody detects endogenous levels of Inhibin β-A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：INHBA;Inhibin beta A chain;Activin beta-A chain;Erythroid differentiation protein;EDF

Observed Band(KD)：52kD

Background： This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016],

Function：function:Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.,online information:Activin entry,similarity:Belongs to the TGF-beta family.,subunit:Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.,

Subcellular Location：Secreted.

Expression： Dermoid cancer,Eye,Fetal brain,Testis,