Target：IL-28
Fields：Cytokine-cytokine receptor interaction;JAK-STAT signaling pathway
Gene Name：IL28A
Protein Name：Interleukin-28A
Human Gene Id：282616
Human Swiss Prot No：Q8IZJ0
Mouse Gene Id：330496
Mouse Swiss Prot No：Q4VK74
Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL28A. AA range:131-180
Specificity：IL-28 Polyclonal Antibody detects endogenous levels of IL-28 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IL28A;IFNL2;ZCYTO20;Interleukin-28A;IL-28A;Cytokine Zcyto20;Interferon lambda-2;IFN-lambda-2
Observed Band(KD)：25kD
Background： This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008],
Function：caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,induction:By viral infections or double stranded RNA.,online information:Interleukin-28 entry,similarity:Belongs to the IL-28/IL-29 family.,
Subcellular Location：Secreted .
Expression： Pooled,
