Target：FOG-2

Fields：MicroRNAs in cancer

Gene Name：ZFPM2

Protein Name：Zinc finger protein ZFPM2

Human Gene Id：23414

Human Swiss Prot No：Q8WW38

Mouse Gene Id：22762

Mouse Swiss Prot No：Q8CCH7

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human ZFPM2. AA range:921-970

Specificity：FOG-2 Polyclonal Antibody detects endogenous levels of FOG-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ZFPM2;FOG2;ZNF89B;Zinc finger protein ZFPM2;Friend of GATA protein 2;FOG-2;Friend of GATA 2;hFOG-2;Zinc finger protein 89B;Zinc finger protein multitype 2

Observed Band(KD)：128kD

Background：zinc finger protein, FOG family member 2(ZFPM2) Homo sapiens The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008],

Function：disease:Defects in ZFPM2 are the cause of diaphragmatic hernia 3 (DIH3) [MIM:610187]; a form of congenital diaphragmatic hernia (CDH). CDH refers to a group of congenital defects in the structural integrity of the diaphragm associated with often lethal pulmonary hypoplasia and pulmonary hypertension.,disease:Defects in ZFPM2 may be a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,domain:The CCHC-type zinc fingers 1, 5, 6 and 8 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC-type zinc finger is essential for the interact

Subcellular Location：Nucleus .

Expression：Widely expressed at low level.