Target：GABA T-1

Fields：Synaptic vesicle cycle;GABAergic synapse

Gene Name：SLC6A1

Protein Name：Sodium- and chloride-dependent GABA transporter 1

Human Gene Id：6529

Human Swiss Prot No：P30531

Mouse Gene Id：232333

Mouse Swiss Prot No：P31648

Rat Gene Id：79212

Rat Swiss Prot No：P23978

Immunogen：The antiserum was produced against synthesized peptide derived from human SLC6A1. AA range:381-430

Specificity：GABA T-1 Polyclonal Antibody detects endogenous levels of GABA T-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SLC6A1;GABATR;GABT1;GAT1;Sodium- and chloride-dependent GABA transporter 1;GAT-1;Solute carrier family 6 member 1

Observed Band(KD)：67kD

Background： The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009],

Function：domain:The PDZ domain-binding motif is involved in the interaction with MPP5.,function:Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.,miscellaneous:This protein is the target of psychomotor stimulants such as amphetamines or cocaine.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,subcellular location:Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons.,subunit:Interacts with MPP5.,

Subcellular Location：Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse . Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity). .

Expression： Brain,