Target：Flt3-L

Fields：MAPK signaling pathway;Ras signaling pathway;PI3K-Akt signaling pathway;Hematopoietic cell lineage;Pathways in cancer

Gene Name：FLT3LG

Protein Name：Fms-related tyrosine kinase 3 ligand

Human Gene Id：2323

Human Swiss Prot No：P49771

Mouse Swiss Prot No：P49772

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human FLT3LG. AA range:171-220

Specificity：Flt3-L Polyclonal Antibody detects endogenous levels of Flt3-L protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FLT3LG;Fms-related tyrosine kinase 3 ligand;Flt3 ligand;Flt3L;SL cytokine

Observed Band(KD)：26kD

Background： Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011],

Function：function:Stimulates the proliferation of early hematopoietic cells. Synergizes well with a number of other colony stimulating factors and interleukins.,subunit:Homodimer (isoform 2).,

Subcellular Location：[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Expression： Brain,Spleen,