Target：FKBP2

Gene Name：FKBP2 FKBP13

Protein Name：Peptidyl-prolyl cis-trans isomerase FKBP2 (PPIase FKBP2) (EC 5.2.1.8) (13 kDa FK506-binding protein) (13 kDa FKBP) (FKBP-13) (FK506-binding protein 2) (FKBP-2) (Immunophilin FKBP13) (Rotamase)

Human Gene Id：2286

Human Swiss Prot No：P26885

Mouse Swiss Prot No：P45878

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：FKBP2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：15kD

Background： The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],

Function：catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Inhibited by both FK506 and rapamycin.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the FKBP-type PPIase family.,similarity:Belongs to the FKBP-type PPIase family. FKBP2 subfamily.,similarity:Contains 1 PPIase FKBP-type domain.,subunit:Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.,tissue specificity:T-cells and thymus.,

Subcellular Location：Endoplasmic reticulum membrane ; Peripheral membrane protein .

Expression：T-cells and thymus.