Target：FBP2

Gene Name：KHSRP

Protein Name：Far upstream element-binding protein 2

Human Gene Id：8570

Human Swiss Prot No：Q92945

Mouse Gene Id：16549

Mouse Swiss Prot No：Q3U0V1

Rat Gene Id：171137

Rat Swiss Prot No：Q99PF5

Immunogen：Synthesized peptide derived from the N-terminal region of human FBP2.

Specificity：FBP2 Polyclonal Antibody detects endogenous levels of FBP2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KHSRP;FUBP2;Far upstream element-binding protein 2;FUSE-binding protein 2;KH type-splicing regulatory protein;KSRP;p75

Observed Band(KD)：73kD

Background： The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010],

Function：function:Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the KHSRP family.,similarity:Contains 4 KH domains.,subcellular location:A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.,subunit:Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and

Subcellular Location：Nucleus . Cytoplasm . A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. .

Expression：Detected in neural and non-neural cell lines.