Target：FAST-1/2

Gene Name：FOXH1

Protein Name：Forkhead box protein H1

Human Gene Id：8928

Human Swiss Prot No：O75593

Mouse Gene Id：14106

Mouse Swiss Prot No：O88621

Immunogen：The antiserum was produced against synthesized peptide derived from human FOXH1. AA range:10-59

Specificity：FAST-1/2 Polyclonal Antibody detects endogenous levels of FAST-1/2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FOXH1;FAST1;FAST2;Forkhead box protein H1;Forkhead activin signal transducer 1;Fast-1;hFAST-1;Forkhead activin signal transducer 2;Fast-2

Observed Band(KD)：40kD

Background： FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008],

Function：domain:The FM region is required for binding smad2/smad4 complexes. FM2 is more effective than FM1 and only interacts with phosphorylated smad2 that is in an activated smad complex.,function:Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).,similarity:Contains 1 fork-head DNA-binding domain.,subunit:Interacts with the MH2 domains of SMAD2 and SMAD3.,tissue specificity:Ubiquitous.,

Subcellular Location：Nucleus.

Expression：Ubiquitous.