Target：FAF1

Fields：Necroptosis

Gene Name：FAF1

Protein Name：FAS-associated factor 1

Human Gene Id：11124

Human Swiss Prot No：Q9UNN5

Mouse Gene Id：14084

Mouse Swiss Prot No：P54731

Rat Gene Id：140657

Rat Swiss Prot No：Q924K2

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human FAF1. AA range:461-510

Specificity：FAF1 Polyclonal Antibody detects endogenous levels of FAF1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FAF1;UBXD12;UBXN3A;CGI-03;FAS-associated factor 1;hFAF1;UBX domain-containing protein 12;UBX domain-containing protein 3A

Observed Band(KD)：75kD

Background： Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008],

Function：function:Potentiates but cannot initiate FAS-induced apoptosis.,similarity:Contains 1 UBX domain.,subunit:Specifically interacts with the cytoplasmic domain of FAS.,tissue specificity:Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.,

Subcellular Location：Nucleus .

Expression：Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.