Target：ETL

Gene Name：ELTD1

Protein Name：EGF latrophilin and seven transmembrane domain-containing protein 1

Human Gene Id：64123

Human Swiss Prot No：Q9HBW9

Mouse Swiss Prot No：Q923X1

Immunogen：The antiserum was produced against synthesized peptide derived from human ELTD1. AA range:251-300

Specificity：ETL Polyclonal Antibody detects endogenous levels of ETL protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ELTD1;ETL;EGF; latrophilin and seven transmembrane domain-containing protein 1;EGF-TM7-latrophilin-related protein;ETL protein

Observed Band(KD)：77kD

Background：developmental stage:Up-regulated in the adult heart.,domain:The transmembrane domain is not required for cleavage, but it is required for dimer formation.,function:Could be involved in cardiac development.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 2 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface.,tissue specificity:Mainly expressed in smooth muscle.,

Function：developmental stage:Up-regulated in the adult heart.,domain:The transmembrane domain is not required for cleavage, but it is required for dimer formation.,function:Could be involved in cardiac development.,PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,similarity:Contains 2 EGF-like domains.,subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface.,tissue specificity:Mainly expressed in smooth muscle.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.