Target：Ribosomal Protein S3

Fields：Ribosome;Pathogenic Escherichia coli infection;Salmonella infection;Coronavirus disease - COVID-19

Gene Name：RPS3

Protein Name：40S ribosomal protein S3

Human Gene Id：6188

Human Swiss Prot No：P23396

Mouse Gene Id：27050

Mouse Swiss Prot No：P62908

Rat Gene Id：140654

Rat Swiss Prot No：P62909

Immunogen：The antiserum was produced against synthesized peptide derived from human RPS3. AA range:171-220

Specificity：Ribosomal Protein S3 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RPS3;OK/SW-cl.26;40S ribosomal protein S3

Observed Band(KD)：30kD

Background： Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and

Function：similarity:Belongs to the ribosomal protein S3P family.,similarity:Contains 1 KH type-2 domain.,

Subcellular Location：Cytoplasm . Nucleus . Nucleus, nucleolus . Mitochondrion inner membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, spindle . In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). .

Expression： Adrenal cortex,Cervix carcinoma,Colon adenocarcinoma,Epithelium,Liver,Lymph,Pituita